Protein Variants | Comment | Organism |
---|---|---|
R217W | mutations of COX15 causing single amino acid conversions associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome results in impaired catalytic function, and the mutation affects oligomeric properties of the enzyme. The mutations affects protein folding and heme binding | Saccharomyces cerevisiae |
S344P | mutations of COX15 causing single amino acid conversions associated with fatal infantile hypertrophic cardiomyopathy and the neurological disorder Leigh syndrome results in impaired stability. The mutations affect protein folding and heme binding | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
multimer | Cox15 exhibits homotypic interactions, forming highly stable complexes dependent upon hydrophobic interactions. This multimerization is evolutionarily conserved and independent of heme levels and heme a synthase catalytic activity. Cox15 multimerization is important for heme a biosynthesis and/or transfer to maturing cytochrome c oxidase | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
COX15 | - |
Saccharomyces cerevisiae |